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The human factor is sometimes just too cumbersome in manufacturing. Take the German chipmaker Infineon: By using an autonomous robot called Scout from MetraLabs for the last several years, the automotive supplier shrank to 10 from 300 the number of minutes it takes to collect the clean-room data needed to measure the presence of rare gases in the air.

Materials science has opened new possibilities for designers of cars, planes and other products. Metal alloys are now as precisely engineered as they are machined. The result is longer lasting, stronger parts. But with a wider selection of materials comes risk—how can you be sure that one piece of gray metal stock is different than another? Careful warehousing procedures and paperwork only go so far.

Cofounder Johannes Trabert, who lives a poetic life in the Thuringian Forest, says the future will be focused on ‘the clever share of work’ between humans and robots.

In the manufacturing industry, the importance of metrology, or the science of measurement, is often underestimated. However, inspection is critical for ensuring products work and operate safely.

When Meyer and Ida Cohen founded Meyda Tiffany Co. in the early 1970s based on a family hobby of making stained glass windows, it’s doubtful that they ever thought it would evolve into the leading U.S. manufacturer of custom and decorative lighting.

When drilling a well, clearing a forest or excavating a building site, experienced operators count on their toughest equipment to help them get the job done.

Road to maturity involves safeguarding supply chains, treating security with the same urgency as safety, for starters.

If you look at all the companies that were on the Fortune 500 list in 1990, “a very large percentage of them are not there anymore,” David Brousell, executive director of the Manufacturing Leadership Council, told people attending his talk on “Manufacturing 4.0” at Oracle’s recent Modern Business Experience conference.

On-time delivery (OTD), a measurement of the level of finish goods or services delivered when promised and in full, is a signal of efficiency that reveals how well operations is doing.

Within manufacturing, a shift has begun to extend big data analytics and condition monitoring beyond the factory door to both ends of the supply chain—to customers, other end users and to second-and third-tier suppliers.